 Guarding your health and well-being involves many things, and therefore we have many opportunities for fulfilling the commandment. Examples are eating healthy food, good sleeping habits, exercise, safety, etc. Maimonides said: "The supports of health are work and moderation, care and cleanliness." Even such a simple thing as wearing boots in an area with snakes, is contributing to this mitzvah.
 "Be careful and guard your soul greatly" - Deuteronomy 4:9; 4:15
It is as forbidden to deprive yourself of pleasures that are allowed, as it is to overindulge. Either way you diminish your strength, and thereby your ability to do mitzvos.
 In keeping with the central theme of avoiding all hazards, the Rabbis forbade a Jew to needlessly or frivolously put him or herself into any dangerous place or situation.
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Shmiras Haguf/